NCT05459883

Splenic Artery Ligation and Portocaval Shunt in Small-for-size Syndrome

Hemodynamic Modulations to Ameliorate Sinusoidal Injuries After Extended Liver Resections: the Role of Splenic Artery Ligation and Porto-caval Shunt in a Series of Patients

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 13 (actual)
• Sponsor: Aretaieion University Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Our study aimed at assessing the changes of portal vein pressure, portal vein flow and hepatic arterial flow (HAF) in liver remnants ≤ 30% of the standard liver volume by reducing portal vein overflow via ligation of the splenic artery.

Detailed description

It has been reported that prevention of acute portal overpressure in small-for-size liver grafts leads to better postoperative outcomes. Accordingly, we aimed to investigate the feasibility of the technique of splenic artery ligation in a case series of patients subjected to major liver resections with evidence of small-for-size syndrome and whether the maneuver results in reduction of portal venous pressure and flow.

Conditions

• Small-For-Size Liver Syndrome
• Ligation
• Liver Regeneration
• Splenic Artery
• Portal Vein
• Ischemia
• Reperfusion Injury
• Hepatectomy

Interventions

Type	Name	Description
PROCEDURE	splenic artery ligation	We identified portal hyperperfusion as a cause of potential small-for-size liver remnant dysfunction and we applied splenic artery ligation as a technically simple procedure to manage the situation

Timeline

• Start date: 2017-01-01
• Primary completion: 2021-12-31
• Completion: 2021-12-31
• First posted: 2022-07-15
• Last updated: 2022-07-15

Locations

1 site across 1 country: Greece