NCT05455047

Study of Metabolic Connectivity in Drug-resistant Temporal Epilepsy

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 90 (actual)
• Sponsor: Central Hospital, Nancy, France · Academic / Other
• Sex: All
• Age: 18 Years – 56 Years
• Healthy volunteers: —

Summary

18F-Fluoro-deoxy-glucose (18F-FDG) positron emission tomography (PET) has a high sensitivity for temporal lobe epilepsy (TLE), the most common form of focal epilepsy, with a detection range of 86-90% . Therefore, 18F-FDG PET is a useful tool to identify the epileptogenic zone (ETZ) in the inter-ictal phase of drug-resistant temporal epilepsy during pre-surgical evaluation . Based on stereotactic electroencephalography (SEEG) findings, a correspondence between electrical data and metabolic changes on PET was found at the group level by identifying four different patterns of TLE . As expected, hypometabolism was not limited to the EZ defined by SEEG, but underlay broader epileptic networks . Because of the different electroclinical presentations of TLE, 18F-FDG PET appears to be a very useful tool in these temporal epilepsies. Indeed, it has been recently demonstrated that a gradient of PET hypometabolism from the uninvolved area to the spreading area, then to the epileptogenic area and to the lesion area is observed with consequently a good performance of 18F-FDG PET in defining the EZ . Therefore, it is interesting to study PET metabolism as a network and not as a combination of regional metabolic measures in epilepsy.

Conditions

• Epilepsy

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	PET-CT at 18F-FDG	PET-CT at 18f6FDG in nuclear medicine departement of Nancy's hospital

Timeline

• Start date: 2022-02-01
• Primary completion: 2022-03-01
• Completion: 2022-06-01
• First posted: 2022-07-13
• Last updated: 2022-08-24

Locations

1 site across 1 country: France