NCT05453916

Comparing the Efficacy of Nitazoxanide Versus Rifaximin in Adult Patients With Irritable Bowel Syndrome Without Constipation

A Randomized Single-Blind Controlled Trial Comparing the Efficacy of Nitazoxanide Versus Rifaximin in Adult Patients With Irritable Bowel Syndrome Without Constipation

• Status: Withdrawn
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: Sadat City University · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

This study aim to compare the efficacy of nitazoxanide in 2-week course of treatment with rifaximin in treating diarrhea associated with IBS. We also aim to study its effect over 10 weeks after treatment to evaluate its efficacy in eradicating symptoms of IBS in the long run.

Conditions

• Irritable Bowel Syndrome With Diarrhea

Interventions

Type	Name	Description
DRUG	Nitazoxanide 500Mg Oral Tablet	patients receiving treatment with Nitazoxanide 500 mg two times daily for 14 days
DRUG	Rifaximin 550Mg Tab	patients receiving treatment rifaximin at a dose of 550 mg three times daily for 14 days

Timeline

• Start date: 2022-07-01
• Primary completion: 2024-07-01
• Completion: 2024-12-31
• First posted: 2022-07-12
• Last updated: 2025-07-14

Locations

1 site across 1 country: Egypt