NCT05451485

VFI in Healthy Vessels

Vector Flow Imaging in Healthy Vessels

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 20 (actual)
• Sponsor: Rijnstate Hospital · Academic / Other
• Sex: All
• Age: 20 Years – 75 Years
• Healthy volunteers: Accepted

Summary

There is a wealth of evidence implicating the important role of blood flow throughout all stages of the process of atherogenesis. Two locations along the vascular tree at which atherosclerotic plaques are typically found are the carotid artery (CA) and the superficial femoral artery (SFA). Nowadays, ultrasound is the technique of choice for assessing the vascular condition in the CA and SFA. However, clinically used ultrasound techniques show a large variability in estimating the blood flow velocity, due to multiple limitations. With the advent of ultrafast ultrasound imaging, (almost) all elements of the transducer can be activated simultaneously. These so-called plane wave acquisition acquires thousands of images per second and makes continuous tracking of blood flow velocities in all directions in the field of view possible. This high-frame-rate acquisition opened up new possibilities for blood flow imaging at the CA and SFA, such as blood Speckle Tracking (bST) and ultrasound Particle Image Velocimetry (echoPIV). Both these vector flow imaging (VFI) techniques enable the quantification of 2D blood flow velocity profiles, where bST uses no contrast agents compared to echoPIV. Beside these novel ultrasound based techniques, 4D Phase Contrast Magnetic Resonance Imaging (4D flow MRI) enables a non-invasive quantification of the 4D blood flow velocity profiles (3D + time) and can be used as reference standard for blood flow assessments in-vivo. We therefore aim to evaluate the performance of both VFI techniques in comparison to 4D flow MRI measurements in the CA and SFA of healthy volunteers.

Conditions

• Carotid Artery Stenosis
• Superficial Femoral Artery Stenosis

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Blood speckle tracking	Blood speckle tracking measurements will be acquired of the carotid artery and superficial femoral artery
DIAGNOSTIC_TEST	Ultrasound particle Imaging Velocimetry	Ultrasound particle imaging velocimetry will be acquired of the carotid artery and superficial femoral artery
DIAGNOSTIC_TEST	4D flow MRI	4D flow MRI will be acquired of the carotid artery and superficial femoral artery
DIAGNOSTIC_TEST	Conventional duplex	Conventional duplex measurements will be acquired of the carotid artery and superficial femoral artery

Timeline

• Start date: 2022-11-05
• Primary completion: 2023-03-18
• Completion: 2023-03-18
• First posted: 2022-07-11
• Last updated: 2023-05-06

Locations

1 site across 1 country: Netherlands