NCT05445427

Vagal Nerve Stimulation for Post COVID Fatigue

Outcomes of Treatment With Vagal Nerve Stimulation in Post-COVID Syndrome: A Pilot Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 18 (actual)
• Sponsor: Mayo Clinic · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to evaluate the impact of vagal nerve stimulation on patients with post COVID syndrome who have fatigue and headache.

Detailed description

Patients, after consenting, will perform questionnaires, have a blood samples taken, and undergo PET/CT scans of the brain. Patients will then be randomized to either receive vagal nerve stimulation, or continue standard clinical care. For those randomized to receive treatment, they will be given a device and asked to follow a specific regimen daily for 12 weeks.

Conditions

• Post COVID Syndrome
• Fatigue
• Headache

Interventions

Type	Name	Description
DEVICE	vagal nerve stimulator	Non-invasive vagus nerve stimulator

Timeline

• Start date: 2022-12-21
• Primary completion: 2024-03-28
• Completion: 2024-03-28
• First posted: 2022-07-06
• Last updated: 2025-03-12
• Results posted: 2025-03-12

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study