NCT05432284

Behavioral Pharmacology of THC and Beta-Myrcene

• Status: Not Yet Recruiting
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 32 (estimated)
• Sponsor: Johns Hopkins University · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Accepted

Summary

This study will evaluate the pharmacokinetics and pharmacodynamics of vaporized b-myrcene and THC administered via inhalation.

Detailed description

The proposed study will be conducted at the Johns Hopkins Behavioral Pharmacology Research Unit (BPRU). Participants will complete 9 acute drug administration periods in which they will administer THC alone, myrcene alone, THC and myrcene together, or placebo. Subjective drug effects and vital signs will be assessed following drug administration. Each participant will receive all 9 dose conditions in a randomized order using a placebo controlled within-subject crossover design. The study will help us understand the individual and interactive effects of THC and b-myrcene, two common constituents found in cannabis.

Conditions

• Cannabis Use

Interventions

Type	Name	Description
DRUG	Placebo	Placebo (ambient air)
DRUG	THC	Pure THC vapor
DRUG	Beta-Myrcene	Pure beta-myrcene vapor

Timeline

• Start date: 2026-07-01
• Primary completion: 2027-11-01
• Completion: 2027-11-01
• First posted: 2022-06-27
• Last updated: 2026-02-13

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study