NCT05431491

Feasibility of Slow Continuous UltraFiltration For Deresuscitation in Critically Ill Patients

Feasibility of Slow Continuous Ultrafiltration With Regional Anticoagulation for Deresuscitation in Critically Ill Patients Though Standard Central or Peripheral Venous Access.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 18 (actual)
• Sponsor: Belfast Health and Social Care Trust · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

To determine the feasibility and safety of deresuscitation using slow continuous ultrafiltration with regional citrate anticoagulation and peripheral or standard central venous access.

Detailed description

Fluid deresuscitation has been shown to have favourable outcomes in the management of the critically ill patient. Whilst diuretic medications have previously been the mainstay of achieving this deresuscitation, the metabolic and biochemical complications associated with their use can limit their application. Mechanical ultrafiltration is another means of achieving fluid deresuscitation and has theoretical benefits over the use of intravenous diuretics. It allows a more titratable process, without the potential metabolic complications. The use of ultrafiltration has been limited by the requirement of wide bore central venous access. The SCUFFD study is a means of assessing whether ultrafiltration with regional anticoagulation can be achieved through standard central or peripheral venous access.

Conditions

• Fluid Overload

Interventions

Type	Name	Description
DEVICE	Ultrafiltration	Ultrafiltration through much smaller intravenous cannula than what has previously been used.

Timeline

• Start date: 2022-08-12
• Primary completion: 2024-12-01
• Completion: 2024-12-01
• First posted: 2022-06-24
• Last updated: 2025-05-02

Locations

1 site across 1 country: United Kingdom