NCT05430490

Cannabis, HIV and Mental Processing Systems

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 276 (actual)
• Sponsor: Washington University School of Medicine · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

This study employs novel methods to identify key determinants and consequences of concurrent HIV infection and regular cannabis use. This study will acquire extensive phenotype data from peripheral and brain markers of immune activation, brain structure, and neuropsychological performance (NP) in persons living with HIV (PLWH) receiving combination anti-retroviral therapy (cART) (80 regular cannabis users and 80 non-users) and HIV uninfected (HIV-) controls (80 regular cannabis users and 80 non-users). This study will provide key insights into the effects of regular cannabis and HIV on peripheral and brain markers of immune function and NP in PLWH and HIV- controls. These insights are critical for cure strategies and ongoing HIV treatment initiatives.

Conditions

• HIV Infections
• Cannabis

Interventions

Type	Name	Description
PROCEDURE	MRI	Multimodal neuroimaging on 3T Prisma Fit MRI
OTHER	NeuroPsychological Testing	A series of written, verbal, and motor tasks requiring the participant to follow instructions, remember words and numbers, draw objects, and complete timed actions.
PROCEDURE	Blood Draw	Laboratory reports (CMP, CBC, Lipids)
OTHER	Questionnaires	Life history, current behaviors, and substance use surveys
PROCEDURE	Lumbar Puncture	Optional procedure which involves obtaining cerebral spinal fluid through a needle in the lower back

Timeline

• Start date: 2022-03-23
• Primary completion: 2026-03-01
• Completion: 2026-03-01
• First posted: 2022-06-24
• Last updated: 2026-04-07

Locations

2 sites across 1 country: United States