NCT05411822

Understanding Circadian Responses to Light in Persons With Mild Cognitive Impairment

Understanding Circadian Responses to Light in Persons With Mild Cognitive Impairment and Alzheimer's Disease

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 36 (actual)
• Sponsor: Icahn School of Medicine at Mount Sinai · Academic / Other
• Sex: All
• Age: 55 Years
• Healthy volunteers: Accepted

Summary

The purpose of this research study is to investigate the relationship between light, the thickness of the pigment at the back of your eye, melatonin levels, and memory. The study will investigate whether changing light distribution pattern from "on-axis"' (i.e., directed along the eye's visual axis to the fovea) to "off-axis" (i.e., directed on the periphery of the eye's visual axis) impact melatonin suppression in 24 mild cognitive impairment participants and 24 healthy, age-matched controls.

Detailed description

Eligible enrolled subjects will be exposed to 4 different lighting conditions in addition to one dark control condition. There will be 5 study session and each one will last for 90 minutes and will be separated by one week. Subjects will collect 3 saliva samples, each one 30 minutes apart for melatonin levels during each study session.

Conditions

• Mild Cognitive Impairment
• Alzheimer Disease

Interventions

Type	Name	Description
DEVICE	Lighting Intervention Blue light	Custom made lighting fixture that will deliver the blue lighting intervention. Blue light (λmax = 451 nm) on axis and off axis.
DEVICE	Lighting Intervention Green light	Custom made lighting fixture that will deliver the green lighting intervention. Green light (λmax = 522 nm) on and off axis
OTHER	Dim-light control condition	(\< 5 lux at the eye) for 30 min

Timeline

• Start date: 2021-06-14
• Primary completion: 2024-05-31
• Completion: 2024-05-31
• First posted: 2022-06-09
• Last updated: 2025-06-24
• Results posted: 2025-06-24

Locations

1 site across 1 country: United States