NCT05401409

Effect of Beetroot Juice on Reducing Hypertension in Autosomal Dominant Polycystic Kidney Disease

Double-Blind, Randomised Placebo-Controlled Study to Determine the Effect of Beetroot Juice on Reducing Blood Pressure in Hypertensive Adults With Autosomal Dominant Polycystic Kidney Disease

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Western Sydney Local Health District · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

People with autosomal dominant polycystic kidney disease (ADPKD) develop high blood pressure and kidney disease. Previous studies have shown that a commonly occurring chemical, nitric oxide (NO), is reduced in ADPKD, and may contribute, in part, to high blood pressure in this condition. Nitrate is found in high concentrations naturally in beetroots, and increases NO. The aim of this study is to determine if beetroot juice reduces blood pressure in hypertensive people with ADPKD.

Conditions

• Autosomal Dominant Polycystic Kidney
• Hypertension
• Endothelial Dysfunction

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Beetroot juice	70mls beetroot juice (400mg nitrate) given daily for 4 weeks
DIETARY_SUPPLEMENT	Nitrate-depleted beetroot juice	70mls beetroot juice (nitrate-depleted) given daily for 4 weeks

Timeline

• Start date: 2022-05-05
• Primary completion: 2023-03-24
• Completion: 2023-03-24
• First posted: 2022-06-02
• Last updated: 2025-06-08
• Results posted: 2025-06-08

Locations

2 sites across 1 country: Australia