NCT05396638

Characterization of Endocannabinoid and Endogenous Opioid Levels in Adolescents With Cannabis Use Disorder

Characterization of Endocannabinoid and Endogenous Opioid Levels in Adolescents

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: University of Colorado, Denver · Academic / Other
• Sex: All
• Age: 14 Years – 25 Years
• Healthy volunteers: Not accepted

Summary

This project seeks to learn more about the effects of cannabis use on the endocannabinoid system and endogenous opioid systems in adolescents to address a fundamental gap in knowledge and identify biomarkers that may help distinguish youth who relapse from youth who remain sober.

Detailed description

Learning the effects of cannabis use on the endocannabinoid system and endogenous opioid systems in adolescents addresses a fundamental gap in knowledge and may identify biomarkers that help distinguish youth who relapse from youth who remain sober. The specific aims of the project are to: 1. Measure endocannabinoid (eCB) and endogenous opioid (endorphin) levels in the blood of adolescents who use cannabis regularly and adolescents who never use cannabis. We expect eCB and endorphin levels to differ significantly in adolescents who use cannabis regularly compared to adolescents who do not. 2. Characterize circulating eCB and endorphin levels at baseline, during abstinence, and after natural resumption of cannabis use. 3. Collect data to evaluate cannabis craving and to test for association of craving with eCB and endorphin levels in adolescents who use cannabis regularly. We expect that larger changes in eCB and endorphin levels will be associated with higher craving scores.

Conditions

• Cannabis Use

Interventions

Type	Name	Description
BEHAVIORAL	Contingency Management	Participants will be paid for abstinence at each study visit.

Timeline

• Start date: 2022-10-13
• Primary completion: 2025-12-01
• Completion: 2025-12-01
• First posted: 2022-05-31
• Last updated: 2025-02-07

Locations

1 site across 1 country: United States