NCT05380739

Memory Training and Neural Plasticity

Working Memory Training and Neural Plasticity in Mild Cognitive Impairment

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: University of Michigan · Academic / Other
• Sex: All
• Age: 60 Years
• Healthy volunteers: Not accepted

Summary

This study will evaluate the efficacy of working memory training in older adults with amnestic mild cognitive impairment (MCI).

Detailed description

Working memory (WM) is the ability to hold information actively in mind and is fundamental for higher-order cognition. This pilot study aims to (1) evaluate the efficacy of WM training in older adults with MCI and (2) understand if and how it works. The study will use behavioral and brain imaging assessments to see whether WM training changes how participants learn and remember information. Functional magnetic resonance imaging (fMRI) and functional near infrared spectroscopy (fNIRS) methods will be used. The study will also use cognitive tests and questionnaires to determine whether participants' cognitive abilities change with training. The study will enroll participants with a diagnosis of MCI as well as cognitively intact older adults (healthy controls, HC).

Conditions

• Mild Cognitive Impairment

Interventions

Type	Name	Description
BEHAVIORAL	Working Memory Training	A 10-session working memory (WM) training program

Timeline

• Start date: 2022-04-07
• Primary completion: 2023-05-11
• Completion: 2023-05-11
• First posted: 2022-05-19
• Last updated: 2025-10-20

Locations

1 site across 1 country: United States