NCT05378295

Personalized Fiber and Insulin Sensitivity

Personalized Microbial Substrates to Prevent Type 2 Diabetes

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 44 (actual)
• Sponsor: Maastricht University Medical Center · Academic / Other
• Sex: All
• Age: 30 Years – 70 Years
• Healthy volunteers: Accepted

Summary

In this project the investigators intend to study the therapeutic potential of a personalized fibre mixture in individuals at high risk of developing T2DM, and aim to address the following key objectives: 1. To investigate whether a mixture of fermentable fibres, which differ in DP and side chains, will stimulate a broad range of SCFA-producing bacterial genera, resulting in enhanced chronic SCFA production throughout the whole colon with a large variation between individuals; 2. To unravel whether providing personalized fibre mixtures, selected based on the individuals' initial microbiota and capacity for SCFA production is crucial to successfully improve host insulin sensitivity and metabolic health

Conditions

• Type 2 Diabetes
• Insulin Resistance

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Fermentable oligosaccharide	Supplementation period 12 weeks
DIETARY_SUPPLEMENT	Personalized fiber mixture	Supplementation period 12 weeks

Timeline

• Start date: 2021-11-05
• Primary completion: 2024-04-22
• Completion: 2024-04-22
• First posted: 2022-05-18
• Last updated: 2024-04-23

Locations

1 site across 1 country: Netherlands