NCT05377411

SMART Stimulation: Precision Neuromodulation of Cognition in Older Adults

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 33 (actual)
• Sponsor: University of Florida · Academic / Other
• Sex: All
• Age: 65 Years – 89 Years
• Healthy volunteers: Accepted

Summary

The current study will investigate methods for enhancing cognitive training (CT) effects in healthy older adults by employing a combination of interventions facilitating neural plasticity and optimizing readiness for learning. A pilot randomized clinical trial will examine the individual and combined impact of pairing cognitive training with transcranial direct current stimulation (tDCS). A precision dosing algorithm will be used to determine the appropriate levels of current and location of electrodes to deliver current using tDCS.

Conditions

• Aging

Interventions

Type	Name	Description
DEVICE	tDCS	During tDCS, a weak electrical current is applied to the scalp that penetrates skin, bone, CSF and the meninges to stimulate underlying cortical and subcortical tissue
BEHAVIORAL	cognitive training	Cognitive Training (CT) will involve up to 10 hours of training over 2-weeks (10 days). CT employs a PositScience BrainHQ suite via its researcher portal. These tasks are web-based and multi-platform (i.e., Windows, Mac). Participants will be randomly assigned to training on 4 tasks focusing on working memory or 4 tasks focusing on attention/speed of processing.

Timeline

• Start date: 2023-01-17
• Primary completion: 2024-06-03
• Completion: 2024-06-03
• First posted: 2022-05-17
• Last updated: 2025-06-26
• Results posted: 2025-06-26

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study