NCT05377372

Early Life Exposures Among Children With Sickle Cell Disease

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: University of Alabama at Birmingham · Academic / Other
• Sex: Female
• Age: 18 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

This study is being conducted to determine the relationship between early childhood exposures, such as Adverse Childhood Experiences, Social Determinants of Health and nutrition/breastfeeding, among children with sickle cell disease, and behavioral interventions aimed to reshape psychological resilience and lifestyle factors towards positive health outcomes.

Detailed description

During year 3 of the award period, 20 mother-infant dyads will be randomly assigned to either a community-based breastfeeding support group or observation. Acceptability to enrollment, intervention adherence for at least 6 months and preliminary effectiveness will be captured. Biomarkers of inflammation, development of asthma and incidences of pain and/or acute chest syndrome will be compared among the intervention and control groups.

Conditions

• Sickle Cell Disease
• Adverse Childhood Experiences
• Breastfeeding

Interventions

Type	Name	Description
BEHAVIORAL	Breastfeeding support group	community-based breastfeeding support group aimed to increase exclusive breastfeeding success rates among Black women
OTHER	Observation	Observe prospectively for breastfeeding initiation, duration and longitudinal health of child with sickle cell disease

Timeline

• Start date: 2026-02-01
• Primary completion: 2027-12-31
• Completion: 2027-12-31
• First posted: 2022-05-17
• Last updated: 2026-02-09

Locations

1 site across 1 country: United States