NCT05377320

PAtient Similarity for Decision-Making in Prevention of Cardiovascular Toxicity (PACT): A Feasibility Study

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 60 (estimated)
• Sponsor: Medical College of Wisconsin · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: —

Summary

This is a single-center, double-arm, open-label, randomized feasibility study that will determine whether a novel clinical decision aid accessed via the electronic health record will be acceptable to both cancer survivors and their cardiologists, will favorably impact appropriate medication use and cardiac imaging surveillance, and will improve clinician and patient decision-making, perception, and behavior towards cardioprotective medication usage and cardiovascular disease imaging utilization.

Detailed description

For this feasibility study, the researchers will create the clinical decision aid and test the central hypothesis that this novel clinical decision aid accessed via the electronic health record will be acceptable to both cancer survivors and their cardiologists and will favorably impact appropriate medication use and cardiac imaging surveillance. The hypothesis is supported by preliminary data suggesting that an initial and rudimentary version of the clinical aid increases appropriate medication use and imaging follow-up in cardio-oncology patients. Success will be determined by ≥85% of clinic visits using the clinical decision aid resulting in pursuit of medication use and cardiac imaging surveillance patterns commensurate with recommendations specific to cancer survivors, with overall rates the same or higher than the group without the clinical decision aid, as well as overall favorable patient and physician focus group comments and survey responses.

Conditions

• Heart Failure
• Coronary Artery Disease
• Peripheral Artery Disease
• Ischemia
• Hypertension
• Diabetes Mellitus
• Cardiomyopathies
• Cardiotoxicity

Interventions

Type	Name	Description
OTHER	Clinical Decision Aid	The clinical decision aid tool will be used at the subject's first visit (Week 0), Week 12 and Week 24.
OTHER	Standard Care	Cardiology clinic visits will take place at the subjects first visit (Week 0), Week 12 and Week 24.

Timeline

• Start date: 2026-12-01
• Primary completion: 2027-12-01
• Completion: 2028-12-01
• First posted: 2022-05-17
• Last updated: 2025-10-14

Locations

1 site across 1 country: United States