Trials / Completed
CompletedNCT05355974
Using Vasopressor Medication to Support Blood Pressure During Intubation Procedure
Vasopressor Utilization to Support Mean Arterial Pressure During Rapid Sequence Intubation: A Clinical Trial (Rapid-Press Trial)
- Status
- Completed
- Phase
- Phase 3
- Study type
- Interventional
- Enrollment
- 42 (actual)
- Sponsor
- Wright State University · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
The purpose of this study is to investigate whether protocolized vasopressor use for patients with normal blood pressure undergoing rapid sequence intubation improves hemodynamic parameters and mitigates adverse events. The hypothesis is that use of vasopressors during Rapid Sequence Intubation will prevent substantial decreases in blood pressure when compared to normal intravenous fluids.
Detailed description
Aim: Prevent 25-46 percent reduction in systolic blood pressure associated with rapid sequence intubation with norepinephrine compared to isotonic fluids alone.
Conditions
- Respiratory Failure
- Hypotension and Shock
- Hypotension on Induction
- Intubation Complication
- Anesthesia Intubation Complication
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Norepinephrine | Norepinephrine continuous infusion at 0.10 mcg/kg/min |
| DRUG | Lactated Ringers, Intravenous | 500mL infusion run at 999mL/hr |
| DRUG | normal saline | 500mL infusion run at 999mL/hr |
| DRUG | Plasma-lyte | 500mL infusion run at 999mL/hr |
Timeline
- Start date
- 2022-08-09
- Primary completion
- 2024-07-10
- Completion
- 2024-07-10
- First posted
- 2022-05-02
- Last updated
- 2024-07-15
Locations
1 site across 1 country: United States
Regulatory
- FDA-regulated drug study
Source: ClinicalTrials.gov record NCT05355974. Inclusion in this directory is not an endorsement.