NCT05350553

Methylglyoxal Evaluation in Humans

A Cross-Sectional Trial of Methylglyoxylated-Protein Levels in Adults With Chronic Pain

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 39 (actual)
• Sponsor: University of Kansas Medical Center · Academic / Other
• Sex: All
• Age: 45 Years – 75 Years
• Healthy volunteers: Accepted

Summary

The investigators will test the hypothesis that patients with low back pain associated with lumbar disc aberrancy will have elevated MGO-protein levels circulating in the blood that are comparable to patients with painful diabetic neuropathy.

Detailed description

This is a cross-sectional, non-interventional study conducted solely at KU Medical Center in which patients will be recruited and sorted based on the following status: 1) healthy, 2) painful diabetic neuropathy, 3) chronic low back pain as a result of non-operative lumbar aberrancy. Once recruited, subjects will undergo a venous blood draw to measure MGO-protein levels, HbA1c, blood glucose, NFL protein levels and GLO1 activity. Subjects will also complete questionnaires to better understand how MGO levels correlate with pain status.

Conditions

• Type 2 Diabetes
• Neuropathy, Painful
• Chronic Low-back Pain
• Lumbar Disc Herniation

Timeline

• Start date: 2022-05-02
• Primary completion: 2025-04-01
• Completion: 2025-04-01
• First posted: 2022-04-28
• Last updated: 2025-04-04

Locations

1 site across 1 country: United States