NCT05346588

THRIVE Feasibility Trial

Feasibility Study for the Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia (THRIVE) Trial

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 300 (actual)
• Sponsor: Washington University School of Medicine · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

To evaluate the feasibility of a pragmatic, large scale, comparative effectiveness, randomized evaluation of patient experience of intravenous propofol versus inhaled volatile anesthesia.

Detailed description

Two-center single-blinded randomized feasibility study, with randomization 1:1 to either propofol TIVA or inhaled volatile general anesthesia for patients who are receiving elective non-cardiac surgery. Patients will be stratified by clinical site with 150 participants per site.

Conditions

• Surgery--Complications
• Anesthesia Complication
• Anesthesia Awareness
• Anesthesia Emergence Delirium
• Anesthesia
• Surgery
• Quality of Life
• Pain, Postoperative
• Nausea, Postoperative
• Anesthesia Morbidity
• Depression
• Sleep Disorders, Circadian Rhythm

Interventions

Type	Name	Description
OTHER	Anesthetic technique Propofol TIVA	Propofol TIVA no inhaled agent
OTHER	Anesthetic technique inhaled agent	must administer inhaled agent.

Timeline

• Start date: 2022-09-29
• Primary completion: 2023-04-16
• Completion: 2023-06-28
• First posted: 2022-04-26
• Last updated: 2023-11-24

Locations

4 sites across 1 country: United States