NCT05339048

The Cartagena Cohort Study

Observational Study for the Analysis of Associations Between Cardiovascular and Respiratory Diseases in a Cohort of Latin American Adults

• Status: Enrolling By Invitation
• Phase: —
• Study type: Observational
• Enrollment: 619 (estimated)
• Sponsor: Universidad de Cartagena · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

Cardiovascular and respiratory diseases are the first and third cause of death, respectively. Cardiovascular risk is known to increase in groups with impaired lung function; however, the mechanisms behind this association are not fully understood. The aim of CaReS is to elucidate the shared pathophysiology of impaired lung function and cardiovascular risk, and to investigate the risk factors associated with them. The CaReS Cohort Study includes adults (18-80 years old) from Cartagena de Indias, a tropical city on Colombian Caribbean Coast, where recent population admixture settled a three-hybrid genetic structure (European, African and Ameridian ancestry). At baseline, the cohort will generate extensive data on -omics (e.g., genomics, transcriptomics, metabolomics, and epigenomics), socio-economic wellbeing, lifestyle, medical history, cardiometabolic, inflammatory and liver function markers, as well as objective measures of ventilatory and cardiovascular performance. The cohort will collect data every three years, for a total period of ten years. Prospective risk of cardiovascular disease and chronic obstructive pulmonary disease (COPD) will be investigated, and their risk factors. Throughout the study period, changes in prevalence, and interactions of various risk factors with these changes will also be ascertained. A predictive risk score for cardiovascular and chronic respiratory disability will be built, using cross-sectional and longitudinal data.

Conditions

• Cardiovascular Diseases
• COPD
• Lung Function Decreased
• Atherosclerosis

Interventions

Type	Name	Description
GENETIC	Genetic risk variants	Exposure: Genetic predisposition to complex diseases.
OTHER	Diet	Exposure: dietary intake of unhealthy foods known to be associated with higher prevalence of respiratory and cardiovascular diseases.
BEHAVIORAL	Physical activity	Exposure: frequency of moderated or intense physical activity, and daily exposure to sedentary behavior.
OTHER	Socio-economic conditions	Exposure: socio-economic vulnerability indexes associated with higher prevalence of respiratory and cardiovascular diseases (including household conditions, accessibility to health care services, among others).

Timeline

• Start date: 2020-10-03
• Primary completion: 2023-10-02
• Completion: 2034-10-02
• First posted: 2022-04-21
• Last updated: 2022-04-21

Locations

1 site across 1 country: Colombia