NCT05314855

Brain Clock and Insulin Resistance

Role of the Central Brain Clock in the Pathophysiology of Insulin Resistance

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 28 (actual)
• Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Academic / Other
• Sex: All
• Age: 25 Years – 65 Years
• Healthy volunteers: Accepted

Summary

In this observational cohort study the investigators will determine the activity rhythm of the suprachiasmatic nucleus in humans with progressive stages of insulin resistance, using advanced functional brain imaging (7 Tesla functional MRI).

Detailed description

Type 2 diabetes mellitus (T2DM) has an increasing worldwide incidence. Insulin resistance is a key pathophysiological process in the development of hyperglycemia in patients with T2DM. Disruption of circadian synchrony leads to insulin resistance. Animal studies and post-mortem human brain studies suggest that the master brain clock in the hypothalamic suprachiasmatic nucleus (SCN) plays a role in the development of insulin resistance. Up to now, no-one has investigated whether the in vivo activity rhythm of the SCN is affected in patients with insulin resistance. The investigators hypothesize that the master brain clock has an important role in the development of human insulin resistance.

Conditions

• Insulin Resistance
• Type 2 Diabetes

Interventions

Type	Name	Description
DEVICE	functional MRI	Subjects will undergo functional MRI at 4 time points in 24 hours.

Timeline

• Start date: 2023-01-04
• Primary completion: 2025-01-18
• Completion: 2025-11-01
• First posted: 2022-04-06
• Last updated: 2026-01-07

Locations

1 site across 1 country: Netherlands