NCT05313828

Effect of Various Treatment Modalities on Dendritic Vial Ulcer

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 40 (estimated)
• Sponsor: Sohag University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Eye infection is a prevalent problem in primary care and remains a crucial healthcare concern. According to the American Academy of Ophthalmology (AAO), herpes simplex virus (HSV) keratitis (HSK) is the leading cause of infectious blindness worldwide . HSK is defined as a corneal inflammatory condition caused by the HSV infection . The global incidence of herpetic keratitis is estimated at 1.5 million per year, resulting in 40,000 new cases of severe visual impairment associated with corneal scarring and opacification . HSV type I (HSV-1) is by far the most predominant causative pathogen of eye infections\]. HSV-1 is also known for causing orolabial herpes, HSV folliculitis, herpes gladiatorum, herpetic whitlow, and eczema herpeticum . HSV can be transferred to the eye by touching an active lesion and then the eye. The National Health and Nutrition Evaluation revealed a seroprevalence of HSV-1 in 53.9% of 14-49 year olds, and 90% of adults 50 years or older , indicating that the majority of the population has been exposed to this virus thus are at risk of developing HSK. In this study we evaluate the efficacy of different treatment modalities on viral keratitis HSK.

Conditions

• Corneal Ulcer

Interventions

Type	Name	Description
DRUG	Acyclovir	acyclovir 4 times /day
DRUG	Tobramycin	tobramycin 4 times /day
DRUG	Fluorometholone	Fluorometholone 4 times/ day
DRUG	Sodium Hyaluronate	Sodium Hyaluronate 4 times/day

Timeline

• Start date: 2022-03-18
• Primary completion: 2022-06-28
• Completion: 2022-07-20
• First posted: 2022-04-06
• Last updated: 2022-04-06

Locations

1 site across 1 country: Egypt