NCT05300737

Symptomatic Carotid Outcomes Registry

Symptomatic Carotid Outcomes Registry With Multi-center Evaluation

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 114 (estimated)
• Sponsor: University of Maryland, Baltimore · Academic / Other
• Sex: All
• Age: 40 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to build upon trials done over 30 years ago, which did not include statins, new antiplatelet agents, and newer antihypertensive medications. Since the landmark trials (NASCET, ECST), there have been new developments in medical stroke prevention, which creates a gap in knowledge. The aim of this study is to evaluate that clinical care with Intensive Medical Therapy (IMT) alone, the one year stroke rate in patients with symptomatic carotid stenosis and low risk clinical features will be \<5%.

Detailed description

This study will only be evaluating clinical care and no interventions will be done specifically for this research. * Informed consent from patient or legally authorized representative. * Participant survey/questionnaire completion at baseline, 6 and 12 months after enrollment * All data collected will be entered into a secure research data registry created for this study.

Conditions

• Carotid Stenosis
• Ischemic Stroke
• Transient Ischemic Attack

Interventions

Type	Name	Description
OTHER	intensive medical therapy	Dual antiplatelet therapy, high potency statins, HTN control, lifestyle modification

Timeline

• Start date: 2022-08-01
• Primary completion: 2026-12-01
• Completion: 2026-12-01
• First posted: 2022-03-29
• Last updated: 2025-10-20

Locations

18 sites across 2 countries: United States, Canada