NCT05284110

Breaking up Sedentary Time in Rheumatoid Arthritis

Breaking up Sedentary Time in Rheumatoid Arthritis: Effects on Vascular Function

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (estimated)
• Sponsor: Liverpool John Moores University · Academic / Other
• Sex: Female
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

This study will verify the effects of breaking up sitting time with short bouts of light intensity walking on vascular function in women with rheumatoid arthritis.

Detailed description

Women diagnosed with rheumatoid arthritis will participate in this randomized crossover trial. In one of the experimental sessions, the participants will remain 4-h on uninterrupted sitting, and in another day they will perform 3-min light intensity walk every 30 min to break up the sitting position. Vascular function will be assessed before and after each intervention using the following devices/techniques: a) transcranial Doppler ultrasound to assess the middle cerebral artery blood flow velocity at baseline and in response to CO2 breathing (5% CO2 mixture for 3 min), and to repeated sit-to-stand transitions; b) a multi-frequency linear transducer (7-12 MHz) attached to a high-resolution ultrasound machine to assess femoral artery dilation after reactive hyperemia (i.e., flow-mediated dilation); c) a laser Doppler probe attached to the skin surface of the right shin in order to quantify the Laser Doppler flux at baseline and during reactive hyperemia. Additionally, healthy age- and body mass-matched women will be recruited and will only perform the pre-intervention tests.

Conditions

• Rheumatoid Arthritis
• Sedentary Behavior
• Endothelial Dysfunction

Interventions

Type	Name	Description
BEHAVIORAL	Physical activity	Multiple bouts of 3-min brisk walking, every 30 min, for 4 hours.

Timeline

• Start date: 2022-12-01
• Primary completion: 2024-04-30
• Completion: 2024-12-01
• First posted: 2022-03-17
• Last updated: 2023-10-04

Locations

1 site across 1 country: United Kingdom