NCT05278052

Standard Maintenance Therapy (SMT) vs Local Consolidative Radiation Therapy and SMT in OM-NSCLC

Standard Maintenance Therapy Versus Local Consolidative Radiation Therapy and Standard Maintenance Therapy in 1-5 Sites of Oligometastatic Non-small Cell Lung Cancer (NSCLC): A Phase III Randomized Controlled Trial

• Status: Recruiting
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 190 (estimated)
• Sponsor: Tata Memorial Hospital · Other Government
• Sex: All
• Age: 18 Years – 99 Years
• Healthy volunteers: Not accepted

Summary

Standard Maintenance Therapy versus Local Consolidative Radiation Therapy and standard maintenance therapy in 1-5 sites of OligoMetastatic Non-small cell lung cancer (NSCLC): A Phase III Randomized Controlled Trial

Detailed description

Standard of care maintenance therapy alone (standard arm) versus local consolidative radiation therapy and standard of care maintenance therapy (Experimental arm)

Conditions

• Oligometastatic Disease
• Metastatic Non Small Cell Lung Cancer

Interventions

Type	Name	Description
RADIATION	Local consolidative radiation therapy	Local consolidative radiation therapy (LCRT) to all oligo-metastatic sites in addition to primary disease site
DRUG	Standard maintenance therapy as decided by the treating medical oncologist	Standard maintenance therapy/Observation

Timeline

• Start date: 2020-04-20
• Primary completion: 2026-04-20
• Completion: 2028-04-20
• First posted: 2022-03-14
• Last updated: 2025-09-10

Locations

1 site across 1 country: India