NCT05266859

Efficacy of PRF and MTA as Compared to Calcium Hydroxide for Pulpotomy in Human Irreversibly Inflamed Permanent Teeth

Comparison of Efficacy of Platelet-rich Fibrin, Mineral Trioxide Aggregate and Calcium Hydroxide as Pulpotomy Medicaments in Permanent Teeth With Irreversible Pulpitis

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 114 (actual)
• Sponsor: Liaquat College of Medicine and Dentistry · Academic / Other
• Sex: All
• Age: 10 Years – 70 Years
• Healthy volunteers: Accepted

Summary

Of all the various pulpotomy medicaments that have been studied till to date, three agents have been selected for this study to compare their efficacy. CH being the control, MTA being one of the most recommended biomaterial and PRF that in addition to being a biomaterial is an autologous agent. Uptil now there have been no prospective trials using these three pulpotomy agents in mature permanent teeth with irreversible pulpitis in our part of the world and even the international studies that have been done utilized different methodologies with no unanimous conclusion. This is the reason that at present this treatment regime (pulpotomy) showing better perspectives cannot be presented with confidence as a predictable treatment option to the patients with irreversible pulpitis. By virtue of this study this challenge is being undertaken. Hypothesis: ALTERNATE HYPOTHESIS There is a difference between the efficacy of the PRF, MTA and CH when used as pulpotomy medicaments in mature permanent teeth with irreversible pulpitis NULL HPOTHESIS There is no difference in efficacy of the PRF, MTA and CH when used as pulpotomy medicaments in mature permanent teeth with irreversible pulpitis

Conditions

• Pulpitis - Irreversible
• Tooth Decay

Interventions

Type	Name	Description
OTHER	Calcium hydroxide	Calcium hydroxide in the power/liquid form will be used and placed on the exposed pulp
OTHER	MTA	Mineral trioxide aggregate will be used as a powder / liquid form and placed over the exposed pulp
OTHER	PRF	PRF will be placed directly over the exposed pulp

Timeline

• Start date: 2019-08-28
• Primary completion: 2021-07-14
• Completion: 2022-01-14
• First posted: 2022-03-04
• Last updated: 2022-08-17

Locations

1 site across 1 country: Pakistan