NCT05258981

The Relationship Between Brain MRI Phenotypes, Genes and Cognitive Outcome in CHD Adults

Exploring the Relationship Between Advanced Multimodal Brain MRI Phenotypes, Genes and Cognitive Outcome in Adults With CHD

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 225 (estimated)
• Sponsor: Boston Children's Hospital · Academic / Other
• Sex: All
• Age: 24 Years – 35 Years
• Healthy volunteers: Accepted

Summary

The main purpose of this proposal is to perform novel MRI analyses to determine the brain organizational changes associated with altered executive function and the modulating role of variants in neuroresilience and hypoxia response genes in adults with d-transposition of the great arteries (d-TGA).

Detailed description

Aim 1 is structured to determine the relationship between sulcal patterns(measured by MRI) and executive function in adults with d-TGA and if this relationship is modified by (a) presence of neuroresilience gene ApoE ε2 or ε4 alleles, or (b) damaging variants in hypoxia response genes. Aim 2 is designed to determine the relationship between structural connectivity using rich club (measured by MRI) and executive function in adults with d-TGA and if this relationship is modified by (a) presence of neuroresilience gene ApoE ε2 or ε4 alleles or (b) damaging variants in hypoxia response genes. In Aim 3, the investigators will determine the relationship between functional connectivity using rich club (measured by MRI) and executive function in adults with d-TGA and if this relationship is modified by (a) presence of neuroresilience gene ApoE ε2or ε4 alleles or (b) damaging variants in hypoxia response genes.

Conditions

• Congenital Heart Disease

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	MRI	Brain MRI

Timeline

• Start date: 2022-07-01
• Primary completion: 2026-01-01
• Completion: 2026-06-01
• First posted: 2022-02-28
• Last updated: 2023-08-15

Locations

1 site across 1 country: United States