NCT05251792

Macular Pigment Optical Density in Primary Angle-closure Disease

Study on the Relationship Between Macular Pigment Optical Density and Primary Angle-closure Disease

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 60 (estimated)
• Sponsor: Zhongshan Ophthalmic Center, Sun Yat-sen University · Academic / Other
• Sex: All
• Age: 40 Years – 90 Years
• Healthy volunteers: Accepted

Summary

Glaucoma is the leading cause of irreversible blindness in the world, and primary angle-closure glaucoma (PACG) is the most important type of glaucoma in Asia. Primary angle closure disease (PACD) is a group of diseases related to PACG, and the pathogenesis is still unclear. Macular pigment has the functions of filtering short-wavelength waves and anti-oxidation, which are related to visual function. Previous studies have found that the macular pigment density (MPOD) is significantly reduced in primary open-angle glaucoma. This project uses the single-wavelength reflection method to measure MPOD, observes the characteristics of PACD and the normal control group's changes in retinal MPOD, and explains the relationship between PACD's MPOD changes and angle-closure glaucoma optic nerve damage

Detailed description

Observation index： Visual acuity，Intraocular pressure，Ophthalmoscope，MPOD，Visual field and OCT. Inspection parameters of OCT： 1. Retinal nerve fiber layer thickness 2. Ganglion cell complex thickness 3. Mean thickness of the central retina 4. Mean defect

Conditions

• Glaucoma
• Glaucoma, Angle-Closure
• Macular Pigment Optical Density

Interventions

Type	Name	Description
OTHER	Ocular examination	All participants underwent a detailed examination, including visual acuity, slit lamp biomicroscopy, direct ophthalmoscopy, optometry noncontact tonometry,MPOD measurement and optical coherence tomography (OCT) measurement

Timeline

• Start date: 2021-11-11
• Primary completion: 2024-03-30
• Completion: 2024-12-30
• First posted: 2022-02-23
• Last updated: 2023-02-13

Locations

1 site across 1 country: China