NCT05243953

Hypersensitivity to Opening of ATP-Sensitive Potassium Channels in Post-Traumatic Headache

Hypersensitivity to Opening of ATP-Sensitive Potassium Channels in Post-Traumatic Headache: A Randomized Clinical Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 21 (actual)
• Sponsor: Danish Headache Center · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The aim is to investigate whether opening of ATP-sensitive potassium (KATP) channels induces headache with migraine-like features in people with persistent post-traumatic headache (PTH) attributed to mild traumatic brain injury (mTBI).

Conditions

• Post-Traumatic Headache

Interventions

Type	Name	Description
DRUG	Levcromakalim	Study participants will be allocated to receive continuous intravenous infusion of 0.05 mg/min (20 ml of 50 mg/ml) levcromakalim.
DRUG	Placebo	Study participants will be allocated to receive continuous intravenous infusion of 20 mL placebo (isotonic saline).

Timeline

• Start date: 2022-03-21
• Primary completion: 2022-07-07
• Completion: 2022-07-07
• First posted: 2022-02-17
• Last updated: 2022-07-08

Locations

1 site across 1 country: Denmark