NCT05242406

Effect of EMST Systemic Inflammation and Oxidative Stress in Patients With Moderate OSAS

Investigation of the Effect of Expiratory Muscle Strength Training Applied at Different Intensities on Systemic Inflammation and Oxidative Stress in Patients With Moderate Obstructive Sleep Apnea Syndrome

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 31 (actual)
• Sponsor: Ahi Evren Chest and Cardiovascular Surgery Education and Research Hospital · Academic / Other
• Sex: Male
• Age: 19 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

It was aimed to investigate the effect of expiratory muscle strength training (EMST) applied at different intensities on systemic inflammation and oxidative stress in patients with moderate obstructive sleep apnea syndrome (OSAS). In the study, 32 male patients diagnosed with moderate OSAS will be included in the study. Participants will then be divided into 2 groups by block randomization. In the three-blind planned study; the first group will receive high-intensity %60 maximum expiratory pressure (MEP) EMST training, and the second group will be given low-intensity 30% of MEP, EMST training for 12 weeks. Disease-related symptoms, disease severity apnea-hypopnea index (AHI), oxidative stress index (OSI) and systemic inflammation level, exercise capacity, respiratory muscle strength, sleep quality, daytime sleepiness, and fatigue severity will be evaluated before and after the study.

Detailed description

Primary outcome measures are; disease severity, oxidative stress index and systemic inflammation. Secondary outcome measurements are; disease-related symptoms, exercise capacity, respiratory muscle strength, sleep quality, daytime sleepiness, and severity of fatigue.

Conditions

• Obstructive Sleep Apnea
• Oxidative Stress
• Respiratory Muscle Training

Interventions

Type	Name	Description
OTHER	Expiratory muscle trainig	This exercise will be used to strengthen forced expiratory muscles.

Timeline

• Start date: 2022-06-01
• Primary completion: 2023-04-01
• Completion: 2023-04-01
• First posted: 2022-02-16
• Last updated: 2023-08-14

Locations

1 site across 1 country: Turkey (Türkiye)