NCT05242081

Study on Opioid-free Anesthesia Protocol With S-ketamine and Propofol

Efficacy and Safety of Opioid-free Anesthesia With Propofol Combined With S-ketamine in Laparoscopic Cholecystectomy: a Multicenter, Randomized, Controlled, Non-inferiority Clinical Study (SKOF - LC)

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 980 (estimated)
• Sponsor: The First Affiliated Hospital with Nanjing Medical University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study was to observe the effects of opioid-free anesthesia with S-ketamine on postoperative analgesia and perioperative hemodynamics in short surgical operations, and to explore the effects of S-ketamine on postoperative awakening time and extubation time, nausea and vomiting, hypoxemia, and delirium.

Conditions

• Opioid Use, Unspecified
• S-ketamine

Interventions

Type	Name	Description
DRUG	S-ketamine	S-ketamine 0.5mg/kg for induction and 0.2mg/kg/h for maintenance
DRUG	Sufentanil	Sufentanil 0.2-0.3μg/kg for induction and remifentanil 0.05-0.15μg/kg/min for maintenance

Timeline

• Start date: 2022-07-01
• Primary completion: 2022-12-01
• Completion: 2023-06-01
• First posted: 2022-02-16
• Last updated: 2022-07-20

Locations

1 site across 1 country: China