NCT05237622

Functional Residual Capacity During Different Levels of High-flow in Preterm Infants

The FUNK-FLOW Study - Functional Residual Capacity During Different Levels of High-flow in Preterm Infants

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: University of Zurich · Academic / Other
• Sex: All
• Age: 73 Hours
• Healthy volunteers: Not accepted

Summary

Although there is a widespread use of HighFlow therapy around the world, there is still uncertainty about the most appropriate initial HighFlow level after nasal continuous positive airway pressure therapy. Higher levels might produce excessive and harmful intra-alveolar pressures exceeding those reached during nasal continuous positive airway pressure therapy. Low levels may not generate sufficient distending pressures, which may result in a loss of functional residual capacity and an increased risk of respiratory failure. Therefore, the aim of this study is to assess the effect of different HighFlow levels on the functional residual capacity and to compare these findings to the functional residual capacity during nasal continuous positive airway pressure therapy.

Conditions

• Infant, Premature, Diseases
• Respiratory Distress Syndrome

Interventions

Type	Name	Description
DEVICE	High Flow	Standard HighFlow therapy after weaning from continuous positive airway pressure therapy will be applied on different flow levels. Starting with a flow level of 8l/min, the flow-rates will be changed every 30 minutes subsequently from 8-6-4-2-4-6-8 l/min. Meanwhile, data on lung volume changes will be measured using electrical impedance tomography.

Timeline

• Start date: 2022-02-19
• Primary completion: 2023-01-13
• Completion: 2023-01-13
• First posted: 2022-02-14
• Last updated: 2024-07-09

Locations

1 site across 1 country: Switzerland