NCT05235711

The Role of Interferon-gamma in Immune Responses to Invasive Candidiasis

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 87 (actual)
• Sponsor: Mayo Clinic · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of the study is to investigate the role of the human immune response to candidemia/invasive candidiasis as it relates to the cytokine interferon-gamma.

Detailed description

In this study, patients with Candida bloodstream infection, peritonitis/intra-abdominal abscess, and pleural empyema will be enrolled. Persistent candidiasis confirmed by culture will be defined as follows: (i) Candida bloodstream infection present for \>48 hours after initiation of effective antifungal treatment and after removal of intravenous devices, (ii) Intra-abdominal infection (peritonitis or abscess) that persists for \>96 hours after source control intervention and effective antifungal treatment, (iii) Pleural empyema that persists for \>96 hours after placement of drainage catheter and effective antifungal treatment. Outcomes in patients with and without persistent candidiasis will be assessed.

Conditions

• Fungal Infection
• Candidiasis

Timeline

• Start date: 2022-02-10
• Primary completion: 2024-08-31
• Completion: 2024-08-31
• First posted: 2022-02-11
• Last updated: 2024-10-09

Locations

1 site across 1 country: United States