NCT05230433

High-fat Meal Challenge in Pediatrics

Implications of Insulin Resistance and Cardiorespiratory Fitness in the Metabolic Response to a High-fat Meal Challenge in Pediatrics

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 15 (actual)
• Sponsor: Dartmouth-Hitchcock Medical Center · Academic / Other
• Sex: All
• Age: 8 Years – 17 Years
• Healthy volunteers: Accepted

Summary

The objective is to determine if how physical fitness, measured using a treadmill maximal oxidative capacity test, is associated with the capacity to metabolize a high-fat meal in pediatrics (ages 8-17 years). Ability to metabolize the meal will be assessed by profiling mitochondrial and extra-mitochondrial fatty acid metabolites. The investigators will test if fatty acid oxidation mediates the relationship between fitness and markers of metabolic health, such as insulin resistance.

Conditions

• Pediatric Obesity
• Insulin Resistance

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	High-fat Challenge	The shake will be composed of a mixture of BOOST Glucose Control(R) (Nestlé Products) supplemented with palm oil. Each participant will consume a volume of liquid equivalent to 25% of their estimated daily caloric needs, calculated by the USDA Dietary Reference Intakes using a moderate activity factor.

Timeline

• Start date: 2022-05-01
• Primary completion: 2022-09-19
• Completion: 2023-12-31
• First posted: 2022-02-09
• Last updated: 2025-09-29
• Results posted: 2025-07-23

Locations

1 site across 1 country: United States