NCT05229328

Study on the Establishment of a System for Early Warning and Prognostic Evaluation of Patients With Sepsis

Study on the Establishment of a System for Early Warning and Prognostic Evaluation

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 300 (estimated)
• Sponsor: Xijing Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Accepted

Summary

Sepsis is a clinical syndrome with high morbidity and high fatality rate in emergency department. Patients with acute liver or kidney injury are more likely to develop Multiple Organ Dysfunction Syndrome(MODS) secondary to the non-hepatic injury group, and the prognosis deteriorates significantly. At present, there is no unified diagnostic criteria for acute liver injury associated with sepsis, and the commonly used prognostic evaluation system is rarely included in liver injury indicators, which is not good for practicality.

Detailed description

The project intends to collect the peripheral blood of the normal population, 24 hours after the onset of sepsis and patients in the recovery period. We will separate and extract plasma, Peripheral Blood Mononuclear Cell(PBMC), and plasma exosomal miRNA, and sequence to find indicators related to disease deterioration and prognosis. And then, we will construct and verify the early warning and prognosis evaluation system. On this basis, the researcher explore cellular and molecular mediated pathological mechanisms of sepsis, and then clarify the treatment target of sepsis.

Conditions

• Sepsis
• Prognosis
• Liver Injury
• Kidney Injury
• Early Waking

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Peripheral blood test	Collect peripheral blood to separate and extract plasma, PBMC, and plasma exosomal miRNA, and sequence to find indicators related to disease deterioration and prognosis

Timeline

• Start date: 2021-10-26
• Primary completion: 2023-12-31
• Completion: 2024-12-31
• First posted: 2022-02-08
• Last updated: 2023-01-31

Locations

1 site across 1 country: China