NCT05227391

Live Birth After Letrozole-stimulated Cycles Versus Hormone Replacement Treatment Cycles for the First Frozen Embryo Transfer in Women With PCOS

Live Birth After Letrozole-stimulated Cycles Versus Hormone Replacement Treatment Cycles for the First Frozen Embryo Transfer in Women With PCOS: a Randomized Controlled Trial

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 1,078 (estimated)
• Sponsor: Reproductive & Genetic Hospital of CITIC-Xiangya · Academic / Other
• Sex: Female
• Age: 20 Years – 38 Years
• Healthy volunteers: Not accepted

Summary

This is a multicenter randomized controlled trial comparing the efficacy and safety of two endometrial preparation protocols for the first frozen embryo transfer cycle in PCOS with whole embryo freezing. Subjects will be randomized to letrozole-stimulated group or hormone replacement treatment group in their first frozen embryo transfer cycle, and their pregnancy and perinatal outcomes during this cycle will be followed up and analysis.

Conditions

• PCOS

Interventions

Type	Name	Description
PROCEDURE	Oral Letrozole	Oral Letrozole at a dose of 2.5mg daily will be started on days 3-5 of the menstrual cycle and will be continued for 5 days.
PROCEDURE	Oral estradiol valerate	Oral estradiol valerate at a dose of 3mg twice daily will be started on days 3-5 of the menstrual cycle.

Timeline

• Start date: 2022-03-16
• Primary completion: 2024-06-30
• Completion: 2024-12-31
• First posted: 2022-02-07
• Last updated: 2023-06-22

Locations

1 site across 1 country: China