NCT05195970

Walnuts and Colon Health

Microbiota, Metabolites and Colon Neoplasia

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 140 (actual)
• Sponsor: UConn Health · Academic / Other
• Sex: All
• Age: 39 Years – 75 Years
• Healthy volunteers: Accepted

Summary

The purpose of this research study is to examine whether adding walnuts to your diet can have a beneficial effect on the gut bacteria population, inflammatory markers in the blood, and the tissue that lines the inside of the colon.

Detailed description

This is a 30-day dietary intervention study where participants will be asked to consume 2 ounces of walnuts daily for 21 days, and at the end of the study period they will come in for a routine colonoscopy. After being informed about the study and potential risks, participants giving written informed consent will first start a 7-day wash-out period where they will be asked to avoid foods high in ellagitannins for the duration of the study. In addition, participants will be asked to complete food and activity questionnaires, a walnut consumption log, and two sets of 3-day dietary records during their participation in the study. Participants will also be asked to provide three urine samples, two blood samples, and two stool samples at multiple time points, and 8-10 colon tissue specimens (biopsies) will be collected during their colonoscopy procedure for the purposes of this study.

Conditions

• Colorectal Cancer
• Diet Habit

Interventions

Type	Name	Description
OTHER	Walnuts	Participants consume 2 ounces of walnuts daily for 21 days

Timeline

• Start date: 2022-01-24
• Primary completion: 2026-01-30
• Completion: 2026-01-30
• First posted: 2022-01-19
• Last updated: 2026-04-17

Locations

2 sites across 1 country: United States