NCT05186077

Brain Circuitry Analysis in Bipolar Disorder

• Status: Terminated
• Phase: —
• Study type: Observational
• Enrollment: 26 (actual)
• Sponsor: Jennifer Sweet · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The goal of this cross-sectional study is to use diffusion-weighted imaging based tractography (DWT) to assess white matter (WM) pathways in treatment-refractory bipolar disorder (REF-BD) and treatment responsive bipolar disorder (RSP-BD) subjects compared to healthy controls (HCs). This project will include a prospective controlled trial to include 50 subjects with REF-BD, 50 patients RSP-BD and 50 healthy volunteers.

Conditions

• Bipolar Disorder

Interventions

Type	Name	Description
OTHER	Magnetic Resonance Imaging	Imaging data for research purposes (high-resolution T1 structural and DWI MRI) will be acquired
OTHER	Psychiatric testing	Subjects will be evaluated using psychiatric assessments
OTHER	Eye-Tracking	Eye-tracking assessments will be done to biases toward positive and negative stimuli including images of neutral, fearful/threatening, sad, and happy.
OTHER	Neuropsychology Evaluation	The neuropsychology evaluation will measure verbal learning/memory, attention/working memory, psychomotor speed, verbal fluency/processing speed, and executive function

Timeline

• Start date: 2020-10-15
• Primary completion: 2025-07-31
• Completion: 2025-07-31
• First posted: 2022-01-11
• Last updated: 2025-10-09

Locations

1 site across 1 country: United States