NCT05185245

Liver Transplantation for Non-Resectable Colorectal Liver Metastasis

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: IRCCS Azienda Ospedaliero-Universitaria di Bologna · Academic / Other
• Sex: All
• Age: 18 Years – 73 Years
• Healthy volunteers: Not accepted

Summary

The study aims to evaluate the efficacy of liver transplantation in the context of non-resectable colorectal liver metastasis. The primary endpoint is the overall survival in this group of patients while the secondary endpoint is the disease-free survival. Patients included in this protocol will be evaluated either for whole or partial liver transplantation from deceased or living donors. Type of different transplantations proposed are as follows: 1. Whole liver graft or partial liver (split) from a deceased donor 2. Partial liver graft retrieved from a deceased donor and orthotopically implanted after having performed a left hepatectomy in the recipient. 3. Partial liver graft retrieved from a deceased donor and heterotopically implanted if total hepatectomy can not be performed. 4. Partial liver graft retrieved from a living donor and orthotopically implanted after having performed total hepatectomy. 5. Partial liver graft retrieved from a living donor and orthotopically implanted after having after having performed a left hepatectomy in the recipient. 6. Partial liver graft retrieved from a living donor and heterotopically implanted if total hepatectomy can not be performed. In cases 2-3-5-6 total hepatectomy of native liver can be secondarily performed after having achieved a proper graft hypertrophy in order to avoid a small for size syndrome

Conditions

• Liver Metastasis Colon Cancer
• Colorectal Cancer

Interventions

Type	Name	Description
PROCEDURE	Liver Transplantation	Liver Transplantation for Non-Resectable Colorectal Liver Metastasis

Timeline

• Start date: 2021-04-01
• Primary completion: 2025-03-30
• Completion: 2030-03-30
• First posted: 2022-01-11
• Last updated: 2022-01-11

Locations

1 site across 1 country: Italy