| Not Yet Recruiting | SAMe in Prevention of Oxaliplatin-associated Liver Injury NCT06258525 | Cedars-Sinai Medical Center | Phase 2 |
| Not Yet Recruiting | Oncolytic Virus (H101) + SBRT + Chemotherapy + Targeted Therapy + Immunotherapy for Unresectable CRLM NCT07381309 | Jun Huang | Phase 2 |
| Recruiting | Electrochemotherapy (ECT) in Patients With Primary Visceral Tumors and/or Secondary Visceral Localizations, of NCT06753136 | Istituto Oncologico Veneto IRCCS | N/A |
| Not Yet Recruiting | Irreversible Electroporation (NanoKnife ®) and Immunotherapy for the Treatment of Stage IV Colorectal Cancer NCT06047015 | University of Saskatchewan | Phase 1 / Phase 2 |
| Not Yet Recruiting | Detecting Colorectal Cancer With Liver Metastatic Lesions Using Novel Precise Imaging Tools NCT06935149 | Primo Biotechnology Co., Ltd | Phase 1 |
| Recruiting | TANGO-LIVER Three Arm Nuclear Growth Observation in Liver Surgery NCT06050200 | Medical University of Warsaw | N/A |
| Recruiting | COLDFIRE-III Trial: Efficacy of Irreversible Electroporation and Stereotactic Body Radiotherapy for Perivascul NCT06185556 | Amsterdam UMC, location VUmc | Phase 2 / Phase 3 |
| Recruiting | Dose Finding, Efficacy and Immunological Response of IP-001 Following MWA or IRE for CRLM NCT06630624 | M.R. Meijerink | Phase 1 / Phase 2 |
| Recruiting | SBRT of Metastases Following Neo-adjuvant Treatment for Colorectal Cancer With Synchronous Liver Metastases NCT05775146 | AHS Cancer Control Alberta | Phase 2 |
| Recruiting | Simultaneous vs. Staged Resection of Colorectal Cancer With Synchronous Liver Metastases NCT06200831 | Oslo University Hospital | N/A |
| Not Yet Recruiting | Preoperative Ketogenic Diet for Reduction of Hepatic Steatosis NCT05884723 | Western University, Canada | N/A |
| Active Not Recruiting | Targeted Treatment Plus Tislelizumab and HAIC for Advanced CRCLM Failed From Standard Systemic Treatment NCT06199232 | Peking University | N/A |
| Recruiting | Prospective Cohort Study on Thermal Ablation of Malignant Liver Tumors NCT06179602 | Leiden University Medical Center | — |
| Completed | TACE Plus HAIC Combined With Regorafenib for Liver Metastasis of Colorectal Cancer Refractory to Standard Trea NCT06071052 | First Affiliated Hospital, Sun Yat-Sen University | Phase 2 |
| Recruiting | Fluorescence-guided Resection Of Colorectal Liver Metastases Using SGM-101 and Indocyanine GREEN NCT05965817 | Leiden University Medical Center | Phase 2 |
| Recruiting | Application of High-dose Insulin Therapy to Improve Liver Function and Regeneration NCT06126419 | McGill University Health Centre/Research Institute of the McGill University Health Centre | N/A |
| Not Yet Recruiting | Hepatopulmonary Radio-sterilization With Immunotherapy NCT06053996 | Sheba Medical Center | N/A |
| Withdrawn | Living Donor Liver Transplantation for CRC Liver Metastases NCT05175092 | University of Wisconsin, Madison | N/A |
| Recruiting | GUIDE.MRD-01-CRC: Clinical Validation and Benchmarking of Top Performing CtDNA Diagnostics - Colorectal Cancer NCT06111105 | Claus Lindbjerg Andersen | — |
| Recruiting | COLLISION RELAPSE Trial NCT05861505 | Amsterdam UMC, location VUmc | Phase 3 |
| Recruiting | On-treatment Biomarkers in Metastatic Colorectal Cancer for Life NCT05755672 | Region Skane | — |
| Completed | I-FIGS Feasibility Study NCT05616039 | University Hospital Plymouth NHS Trust | N/A |
| Recruiting | Improving Survival of COlorectal LIver Metastases by RFA-mediated Immunostimulation NCT04798898 | University of Aarhus | N/A |
| Recruiting | LT for Unresectable Colorectal Liver Metastasis NCT04874259 | Seoul National University Hospital | N/A |
| Completed | Clinical Validation of a Fractional Administration Device for Holmium-166 SIRT NCT05183776 | Radboud University Medical Center | N/A |
| Recruiting | Gadoxetate Abbreviated MRI in Metastatic Colorectal Cancer NCT05314400 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | N/A |
| Terminated | Study of Intra-Arterial Oxaliplatin Plus Capecitabine to Treat Liver Metastases From Colorectal Cancer NCT04701281 | AllVascular | Phase 1 / Phase 2 |
| Unknown | Hepatic Arterial Infusion Chemotherapy With Fruquintinib for Colorectal Cancer Liver Metastases As Third-line NCT05406206 | Peking University Cancer Hospital & Institute | Phase 2 |
| Unknown | Surgery Outcome Treated by Neo-adjuvant Combination of Oxaliplatin, Irinotecan, Folinic Acid and Fluorouracil NCT05362825 | Cho Ray Hospital | — |
| Recruiting | LDLT in Non Resectable Colo-rectal Cancer Liver Metastasis NCT05186116 | Azienda Ospedaliero-Universitaria di Modena | N/A |
| Active Not Recruiting | Chemoembolization (Lifepearls-Irinotecan) in Patients With Colorectal Cancer and Metastatic Disease NCT04595266 | Grupo Espanol Multidisciplinario del Cancer Digestivo | Phase 2 |
| Unknown | FOLFOXIRI Plus Cetuximab Versus FOLFOXIRI Plus Bevacizumab in Conversion Therapy of Right-sided Colon Cancer L NCT04832776 | Fudan University | Phase 2 |
| Recruiting | Liver Transplantation for Non-Resectable Colorectal Liver Metastasis NCT05185245 | IRCCS Azienda Ospedaliero-Universitaria di Bologna | N/A |
| Active Not Recruiting | Precision Medicine for Liver Tumours With Quantitative Magnetic Resonance Imaging and Whole Genome Sequencing NCT04597710 | Perspectum | — |
| Suspended | DNX-2440 for Resectable Colorectal Liver Metastasis NCT04714983 | DNAtrix, Inc. | Phase 1 |
| Unknown | Effect of the Laparoscopic Approach in Reducing Postoperative Severe Complications Following Hepatectomy for C NCT04163887 | Institut Mutualiste Montsouris | N/A |
| Unknown | Sonazoid-enhanced Ultrasound for the Detection of Colorectal Liver Metastases Less Than 2 cm NCT04686942 | Sun Yat-sen University | — |
| Unknown | COLLISION XL: Unresectable Colorectal Liver Metastases (3-5cm): Stereotactic Body Radiotherapy vs. Microwave A NCT04081168 | Amsterdam UMC, location VUmc | N/A |
| Recruiting | Biopsy After Radioembolization to Identify Changes in Tumor Cells From the Radiation NCT04668872 | Memorial Sloan Kettering Cancer Center | — |
| Recruiting | Selective Internal Radiation Therapy With 90Y Resin Micropheres for Refractory Colorectal Cancer Liver Metasta NCT04491929 | Aarhus University Hospital | — |
| Terminated | Immunotherapy With Y90-RadioEmbolization for Metastatic Colorectal Cancer NCT04108481 | University of Iowa | Phase 1 |
| Unknown | Colorectal Liver Metastases: Novel Assessment Tools for Technical Resectability NCT04270851 | University of Manchester | — |
| Unknown | Treatment With Hepatic Arterial Infusion of Oxaliplatin in Combination With Systemic FOLFIRI Chemotherapy and NCT04003792 | Rabin Medical Center | Phase 2 |
| Active Not Recruiting | Phase 1b Study to Evaluate ATP128, VSV-GP128 and BI 754091, in Patients With Stage IV Colorectal Cancer NCT04046445 | Amal Therapeutics | Phase 1 |
| Completed | Simultaneous Portal and Hepatic Vein Versus Portal Vein Embolizations for Hypertrophy of the Future Liver Remn NCT03841305 | University Hospital, Montpellier | Phase 2 |
| Unknown | The CLiFF Study: Change in Liver Function and Fat in Pre-operative Chemotherapy for Colorectal Liver Metastase NCT03562234 | University of Manchester | — |
| Unknown | TACE Associated to Systemic Bevacizumab for the Treatment of Refractory Liver Metastases From Colorectal Cance NCT03732235 | Giammaria Fiorentini | — |
| Unknown | Prospective Clinical Study of Intraoperative Assessment of Resection Margin of Colo-Rectal Cancer Liver Metast NCT04634526 | Oncology Institute of Vojvodina | — |
| Recruiting | Microwave Ablation for Treatment of Small Renal Tumors and Primary and Secondary Liver Neoplasms NCT03981497 | Francesco De Cobelli | — |
| Unknown | COLLISION Trial - Colorectal Liver Metastases: Surgery vs Thermal Ablation NCT03088150 | Amsterdam UMC, location VUmc | N/A |
| Unknown | Treatment Response Evaluation in Patients With Non-resectable Colorectal Liver Metastases A Feasibility Study NCT03444194 | Odense University Hospital | N/A |
| Completed | Simultaneous Resection of Colorectal Cancer With Synchronous Liver Metastases NCT02954913 | Hamilton Health Sciences Corporation | N/A |
| Unknown | FGF19 in Obstructive Cholestasis: "Unveil the Signal" NCT05718349 | Nicole Hildebrand | — |