NCT05177900

Interphase Gap in Biphasic Stimulation in DBS for ET

Investigating the Use of an Interphase Gap in Biphasic Pulses in DBS for ET Patients

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 9 (actual)
• Sponsor: Myles Mc Laughlin · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Deep Brain Stimulation (DBS) is a well established therapy in medication-refractory essential tremor (ET). Since the inception of DBS, cathodic pulses are used. Recent work suggests that biphasic pulses influence the therapeutic window when compared to cathodic pulses, when tested acutely. Animal studies and work from cochlear implants, show that the use of an interphase gap, influences the generation of action potentials. In this study, the goal is to investigate the use of an interphase gap in biphasic pulses in DBS for ET patients.

Conditions

• Essential Tremor

Interventions

Type	Name	Description
DEVICE	Study Tool Computer	Nonconventional pulses delivered with custom-ware designed by Boston Scientific

Timeline

• Start date: 2021-12-01
• Primary completion: 2022-01-27
• Completion: 2022-01-27
• First posted: 2022-01-05
• Last updated: 2022-04-06

Locations

1 site across 1 country: Belgium