NCT05171725

Multidisciplinary Expert System for the Assessment & Management of Complex Brain Disorders

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 635 (actual)
• Sponsor: Neurological Institute of Athens · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Accepted

Summary

The Multidisciplinary Expert System for the Assessment \& Management of Complex Brain Disorders (MES-CoBraD) is an interdisciplinary project combining Real-World Data (RWD) from multiple clinical and consumer sources through comprehensive, cost-efficient, and fast protocols towards improving diagnostic accuracy and therapeutic outcomes in people with Complex Brain Disorders (CoBraD), as reflected in Neurocognitive (Dementia), Sleep, and Seizure (Epilepsy) disorders and their interdependence. It brings together internationally recognized experts in medicine, engineering, computer science, social health science, law, and marketing and communication from across Europe, and combines clinical information and scientific research in CoBraD with technical innovation in secure data-sharing platforms, artificial intelligence algorithms, and expert systems of precision and personalized care, with a primary focus on improving the quality of life of patients, their caregivers, and the society at large. It leverages RWD from diverse CoBraD populations across cultural, socioeconomic, educational, and health system backgrounds, with special attention on including vulnerable populations and minorities in an equitable manner and engaging key stakeholders to maximize project impact.

Conditions

• Dementia
• Alzheimer Disease
• Epilepsy
• Sleep Disorder
• Circadian Rhythm Disorders
• Healthy

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	EEG,PSG	concurrent overnight sleep study with full electroencephalography (in-lab or at home)
DIAGNOSTIC_TEST	biosample collection (blood and CSF)	blood or CSF collection for analyses of neurodegenerative, inflammatory, and, per condition, genetic information
DIAGNOSTIC_TEST	neuropsychological testing	paper and pencil, as well as tablet based cognitive testing
DIAGNOSTIC_TEST	actigraphy	week long actigraphy assessment with concurrent sleep diary acquisition
DIAGNOSTIC_TEST	clinician assessment	standard clinical assessment by an expert clinician in the respective field of brain disorders

Timeline

• Start date: 2021-04-01
• Primary completion: 2024-09-30
• Completion: 2024-09-30
• First posted: 2021-12-29
• Last updated: 2026-04-02

Locations

4 sites across 4 countries: Greece, Israel, Spain, United Kingdom