NCT05170217

Reducing the Harmful Effects of Cannabis Use: Finding the Optimal CBD:THC Ratio

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 46 (actual)
• Sponsor: King's College London · Academic / Other
• Sex: All
• Age: 21 Years – 50 Years
• Healthy volunteers: Accepted

Summary

This study will recruit healthy volunteers who use cannabis infrequently. Each participant will attend the laboratory on five occasions: an initial visit to check that they are safe to join the study and four days of testing. Participants will be administered, in a randomized order, vaporized cannabis containing one of four different ratios of CBD:THC (0:1, 1:1, 2:1, 3:1). The cannabis administration will follow a standardised inhalation procedure using a medical-grade vaporizer device. Participants will complete a series of tasks measuring cognition, psychosis, anxiety and other subjective experiences. The study will be carried out at the NIHR-Wellcome Trust Clinical Research Facility at King's College Hospital.

Conditions

• Cannabis Use

Interventions

Type	Name	Description
DRUG	THC	Inhaled cannabis containing 10mg THC
DRUG	Cannabidiol	Inhaled cannabis containing 10mg CBD
DRUG	Cannabidiol	Inhaled cannabis containing 20mg CBD
DRUG	Cannabidiol	Inhaled cannabis containing 30mg CBD

Timeline

• Start date: 2017-11-08
• Primary completion: 2019-06-09
• Completion: 2019-06-09
• First posted: 2021-12-27
• Last updated: 2021-12-27

Locations

1 site across 1 country: United Kingdom