NCT05167734

Practical Anemia Bundle for SusTained Blood Recovery

The Practical Anemia Bundle for SusTained Blood Recovery (PABST-BR) Clinical Trial

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 100 (actual)
• Sponsor: Mayo Clinic · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to test a multi-faceted anemia treatment plan to reduce the severity of anemia and to promote hemoglobin and functional recovery in adults who have been in the intensive care unit (ICU).

Detailed description

Anemia is common during critical illness and is associated with impaired outcomes during and after hospitalization. The goal of this investigation is to test a multi-faceted anemia prevention and targeted treatment bundle to attenuate anemia development and promote functional recovery in the setting of critical illness. Specifically, this will be a pragmatic phase II clinical trial of a multi-faceted anemia prevention and treatment bundle with 3 aspects (optimized phlebotomy practice, clinical decision support, targeted pharmacologic anemia treatment) assessing the impact of the intervention on hemoglobin concentrations (primary aim), transfusion utilization, and functional outcomes through 3 months after hospitalization.

Conditions

• Anemia
• Critical Illness

Interventions

Type	Name	Description
DRUG	Iron Dextran	1000 mg IV
DRUG	Erythropoietin (EPO)	40,000 units subcutaneous

Timeline

• Start date: 2021-11-30
• Primary completion: 2024-03-04
• Completion: 2024-11-26
• First posted: 2021-12-22
• Last updated: 2025-04-06
• Results posted: 2025-04-06

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study