NCT05154864

Ultrafiltration in Pediatric Cardiac Surgery: An Observational Cohort Study

The Optimal Ultrafiltration Protocol in Pediatric Cardiac Surgery: An Observational Cohort Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 40 (actual)
• Sponsor: IWK Health Centre · Academic / Other
• Sex: All
• Age: 15 Years
• Healthy volunteers: Not accepted

Summary

Infants and children undergoing cardiac surgery with cardiopulmonary bypass (CPB) can experience systemic inflammation that prolongs post-operative recovery. Ultrafiltration is an intra-opreative technique that is hypothesized to extract circulating inflammatory mediators during the CPB time. There have been only a few small studies looking at a limited number of inflammatory marker profiles in this context. Our institution uses an innovative form of ultrafiltration "subzero-balance simple-modified ultrafiltration" (SBUF-SMUF) throughout the entire CPB time. SBUF-SMUF has been our standard of care for the last 5 years. This observational seeks to describe the clinical and immunologic outcomes of infants and children undergoing cardiac surgery with CBP and SBUF-SMUF.

Conditions

• Congenital Heart Disease
• Inflammation

Interventions

Type	Name	Description
PROCEDURE	SBUF-SMUF	Intra-operative continuous ultrafiltration

Timeline

• Start date: 2020-08-01
• Primary completion: 2021-06-30
• Completion: 2021-06-30
• First posted: 2021-12-13
• Last updated: 2022-01-03

Locations

1 site across 1 country: Canada