NCT05149157

Trajectories and Mechanisms of Recovery From Malaria: An Observational Study

Search for Correlates of Recovery in the Patient Transcriptome (SCRIPT) (Malaria) Study

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 240 (estimated)
• Sponsor: Imperial College London · Academic / Other
• Sex: All
• Age: 8 Days
• Healthy volunteers: Not accepted

Summary

This observational research study aims to answer the question: 'Which aspects of human biology play an important role in recovery from symptomatic malaria?' In particular, the researchers aim to identify human genes for which the level of gene activity reflects the patient's overall rate of recovery. The researchers believe this approach may reveal new targets for adjunctive therapies. The researchers aim to recruit 240 people, of all ages, who have been diagnosed with symptomatic malaria at selected hospitals in London. Blood samples, urine samples, and clinical information will be collected over the 14 days following malaria diagnosis.

Conditions

• Malaria

Interventions

Type	Name	Description
OTHER	Symptomatic malaria	This observational study will be recruiting patients who have symptomatic malaria (confirmed by presence of asexual stage parasitaemia of any Plasmodium species on blood film)

Timeline

• Start date: 2022-08-02
• Primary completion: 2026-01-05
• Completion: 2026-01-05
• First posted: 2021-12-08
• Last updated: 2025-02-19

Locations

1 site across 1 country: United Kingdom