NCT05139862

Neurocardiac Predictors of Treatment Response to RTMS in Depression

Neuro-cardiac Predictors of Treatment Response to RTMS in Depression: a Mechanistic Study Using Interleaved TMS-fMRI

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 110 (estimated)
• Sponsor: University of British Columbia · Academic / Other
• Sex: All
• Age: 19 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Heartbeat is controlled by the brain and is regular but flexible to change in response to environmental and internal stimuli. This feature is known as heart rate variability (HRV). Major depressive disorder (MDD) has been associated with diminished HRV and this is a reflection of abnormal brain function caused by MDD. Repetitive transcranial magnetic stimulation (rTMS) is a treatment that stimulates specific areas of the brain. The goal of this study is to test the hypothesis that rTMS induces changes in connectivity between the area of the brain stimulated with rTMS and deeper areas in the brain associated to heart rate regulation. 110 patients with TRD will be recruited and will undergo a concurrent TMS-fMRI session before receiving a course of iTBS to the L-DLPFC for 30 sessions at 120% rMT.

Conditions

• Depression
• Treatment Resistant Depression

Interventions

Type	Name	Description
DEVICE	Repetitive Transcranial Magnetic Stimulation	This study utilizes intermittent theta burst stimulation (iTBS) to the left DLPFC.

Timeline

• Start date: 2025-05-01
• Primary completion: 2028-12-01
• Completion: 2028-12-01
• First posted: 2021-12-01
• Last updated: 2024-12-24

Locations

1 site across 1 country: Canada