NCT05138640

Bone Strength and Physical Activity in Patients With a Recent Clinical Fracture

Prospective Evaluation of Bone Strength, Physical Activity, Falls, Subsequent Fractures and Mortality in Patients Presenting With a Recent Clinical Fracture

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 500 (actual)
• Sponsor: Joop P.W. van den Bergh · Academic / Other
• Sex: All
• Age: 50 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

The risk for a subsequent fracture is significantly higher in patients presenting with a fracture compared to individuals without a previous fracture and is highest within the first 2 years after the initial fracture. The risk for a subsequent fracture is not dependent of BMD as measured by conventional DXA. In recent studies, it has been shown that HRpQCT measurements provide information about bone structure, bone quality and bone strength in addition to BMD measurements. Diagnostic strategies should be focussed on bone quality and bone strength and fall prediction in the patients at high risk for falls, subsequent fracture and mortality such as patients with a recent fracture. Therefore, the investigators conduct a prospective observational study in 500 patients aged 50 years and older who present with a clinical fracture for evaluation of bone strength, physical activity, falls, subsequent fractures and mortality during a follow-up period of 3 years.

Conditions

• Fractures, Bone
• Patient Fall
• Osteoporosis
• Physical Activity

Interventions

Type	Name	Description
OTHER	Not applicable. The study is designed as an observational cohort study	Not applicable. The study is desigend as an observational cohort study

Timeline

• Start date: 2014-10-01
• Primary completion: 2019-07-01
• Completion: 2019-07-01
• First posted: 2021-12-01
• Last updated: 2021-12-01

Locations

1 site across 1 country: Netherlands