NCT05136235

Pulmonary Hypertension in Extremely Preterm Infants

Pulmonary Hypertension in Extremely Preterm Infants - A Prospective Cohort Study

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 350 (estimated)
• Sponsor: Universitair Ziekenhuis Brussel · Academic / Other
• Sex: All
• Age: 2 Weeks
• Healthy volunteers: Not accepted

Summary

Extremely preterm infants are at risk for developing bronchopulmonary dysplasia (BPD) and associated chronic pulmonary hypertension (PH), a consequence of altered pulmonary vasculature. This condition occurs in about 25% of babies with BPD, and the association grows with increasing BPD severity. Other risk factors have been described as well. Morbidity and mortality associated with prematurity and/or BPD increase significantly in the presence of PH. Thus, international guidelines encourage the use of standardized screening protocols for this condition. However, several questions regarding these recommendations are left unanswered, such as a clear definition for PH in this population. The research aim is to prospectively evaluate prevalence, risk factors and clinical course of PH in these children. The investigators aim to identify at-risk infants early on and ultimately improve survival making use of an early targeted intervention.

Conditions

• Bronchopulmonary Dysplasia
• Pulmonary Hypertension
• Premature Birth

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Echocardiography	There will be screened for pulmonary hypertension by means of serial echocardiographies during the study period
DIAGNOSTIC_TEST	NT-proBNP	At 36 weeks postmenstrual age there will be screened for pulmonary hypertension by means of an NT-proBNP measurement in a blood sample

Timeline

• Start date: 2022-01-01
• Primary completion: 2025-12-01
• Completion: 2025-12-01
• First posted: 2021-11-29
• Last updated: 2021-11-29