Trials / Completed
CompletedNCT05132933
Gas Exchange Derangement Physiopathology in Critically Ill Patients With COVID-19
Gas Exchange Derangement Physiopathology and Response to Different Levels of Positive End-expiratory Pressure in Critically Ill Patients With COVID-19
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 14 (actual)
- Sponsor
- Policlinico Hospital · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
The study was designed to understand the pathophysiology of gas exchange derangement in critically ill patients with COVID-19. Specifically we will evaluate the effect of 3 different levels of positive end-expiratory pressure (PEEP) and two different levels of inspiratory oxygen fraction (FiO2) on gas exchange by analyzing shunt and dead space. Furthermore, complete respiratory mechanics and distribution of ventilation and perfusion by electrical impedance tomography will be assessed at each level of PEEP.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | PEEP trial - Electrical Impedance Tomography | Three different levels of PEEP and two different levels of FiO2 will be tested without changing anything else in the baseline patient ventilation |
Timeline
- Start date
- 2021-10-01
- Primary completion
- 2022-06-30
- Completion
- 2022-12-30
- First posted
- 2021-11-24
- Last updated
- 2024-01-25
Locations
1 site across 1 country: Italy
Source: ClinicalTrials.gov record NCT05132933. Inclusion in this directory is not an endorsement.